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Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic generated by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the moms and dad substance lincomycin.

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Non-active substances: 75 mg-- corn carbohydrate, FD&C blue no. 1, FD&C yellow no. 5, jelly, carbohydrate, magnesium mineral stearate, as well as talc; 150 mg-- corn carbohydrate, FD&C blue no. 1, FD&C yellow no. 5, gelatin, carbohydrate, magnesium mineral talc, titanium and stearate dioxide; 300 milligrams-- corn starch, FD&C blue no. 1, gelatin, lactose, magnesium mineral stearate, titanium, as well as talc dioxide.


The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6, 7, 8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Serum degree studies with a 150 mg oral dosage of clindamycin hydrochloride in 24 normal grown-up volunteers showed that clindamycin was rapidly taken in after oral management. An average peak lotion level of 2.50 mcg/mL was reached in 45 mins; lotion levels balanced 1.51 mcg/mL at 3 hrs and also 0.70 mcg/mL at 6 hrs. Absorption of an oral dose is essentially complete (90 %), as well as the concomitant management of food does not significantly customize the serum focus; lotion levels have actually been foreseeable and also consistent from person to individual and dosage to dose. Serum degree research studies adhering to multiple doses of Cleocin HCl for approximately 14 days show no evidence of accumulation or modified metabolic rate of medication. Doses of approximately 2 grams of clindamycin each day for 14 days have actually been well allowed by healthy volunteers, except that the incidence of gastrointestinal negative side effects is better with the greater dosages.

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